:root{--primary: #0d9488;--primary-hover: #0f766e;--primary-light: #f0fdfa;--secondary: #0f172a;--accent: #2dd4bf;--bg-main: #f8fafc;--bg-card: #ffffff;--bg-sidebar: #0f172a;--text-main: #1e293b;--text-muted: #64748b;--text-on-dark: #f8fafc;--border: #e2e8f0;--success: #10b981;--warning: #f59e0b;--danger: #ef4444;--info: #3b82f6;--shadow-sm: 0 1px 2px 0 rgb(0 0 0 / .05);--shadow: 0 4px 6px -1px rgb(0 0 0 / .1), 0 2px 4px -2px rgb(0 0 0 / .1);--shadow-lg: 0 10px 15px -3px rgb(0 0 0 / .1), 0 4px 6px -4px rgb(0 0 0 / .1);--radius: .75rem;--mobile: 768px;--tablet: 1024px}:root[data-theme=dark]{--primary: #14b8a6;--primary-hover: #0d9488;--primary-light: #042f2e;--secondary: #cbd5e1;--accent: #2dd4bf;--bg-main: #0f172a;--bg-card: #1e293b;--bg-sidebar: #0f172a;--text-main: #f8fafc;--text-muted: #94a3b8;--text-on-dark: #f8fafc;--border: #334155;--shadow-sm: 0 1px 2px 0 rgb(0 0 0 / .5);--shadow: 0 4px 6px -1px rgb(0 0 0 / .5), 0 2px 4px -2px rgb(0 0 0 / 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var(--xy-resize-background-color-default));border-width:0;border-style:solid}.react-flow__resize-control.line.left,.react-flow__resize-control.line.right{width:1px;transform:translate(-50%);top:0;height:100%}.react-flow__resize-control.line.left{left:0;border-left-width:1px}.react-flow__resize-control.line.right{left:100%;border-right-width:1px}.react-flow__resize-control.line.top,.react-flow__resize-control.line.bottom{height:1px;transform:translateY(-50%);left:0;width:100%}.react-flow__resize-control.line.top{top:0;border-top-width:1px}.react-flow__resize-control.line.bottom{border-bottom-width:1px;top:100%}.react-flow__edge-textbg{fill:var(--xy-edge-label-background-color, var(--xy-edge-label-background-color-default))}.react-flow__edge-text{fill:var(--xy-edge-label-color, var(--xy-edge-label-color-default))}:root{--primary-color: #4f46e5;--primary-hover: #4338ca;--bg-color: #f8fafc;--card-bg: #ffffff;--text-main: #1e293b;--text-muted: #64748b;--danger: #ef4444;--warning: #f59e0b;--success: #10b981;--border-radius: 12px;--shadow: 0 4px 6px -1px rgb(0 0 0 / .1), 0 2px 4px -2px rgb(0 0 0 / .1);--input-bg: #ffffff;--input-border: #e2e8f0}:root[data-theme=dark]{--primary-color: #818cf8;--primary-hover: #6366f1;--bg-color: #0f172a;--card-bg: #1e293b;--text-main: #f8fafc;--text-muted: #94a3b8;--input-bg: #0f172a;--input-border: #334155}body{margin:0}.container{display:flex;flex-direction:column;gap:2rem}header{text-align:center;margin-bottom:1rem}header h1{font-size:2.5rem;margin:0;background:linear-gradient(to right,var(--primary-color),var(--primary-hover));background-clip:text;-webkit-background-clip:text;-webkit-text-fill-color:transparent}.search-section{position:relative;background:var(--card-bg);padding:1.5rem;border-radius:var(--border-radius);box-shadow:var(--shadow)}.search-input-wrapper{position:relative}input[type=text]{width:100%;padding:.75rem 1rem;border:1px solid var(--input-border);background-color:var(--input-bg);color:var(--text-main);border-radius:8px;font-size:1rem;box-sizing:border-box;transition:border-color .2s,background-color .3s,color .3s}input[type=text]:focus{outline:none;border-color:var(--primary-color);box-shadow:0 0 0 2px var(--primary-color)}.suggestions{position:absolute;top:100%;left:0;right:0;background:var(--card-bg);border:1px solid #e2e8f0;border-radius:8px;margin-top:.5rem;max-height:200px;overflow-y:auto;z-index:10;box-shadow:var(--shadow)}.suggestion-item{padding:.75rem 1rem;cursor:pointer;transition:background-color .2s}.suggestion-item:hover{background-color:var(--primary-light, #f1f5f9)}.selected-drugs{display:flex;flex-direction:column;gap:1rem}.drug-list{display:flex;flex-wrap:wrap;gap:.5rem}.drug-tag{background:#e0e7ff;color:var(--primary-color);padding:.5rem 1rem;border-radius:20px;display:flex;align-items:center;gap:.5rem;font-weight:500}.remove-btn{background:none;border:none;color:var(--danger);cursor:pointer;font-size:1.2rem;display:flex;align-items:center;justify-content:center;padding:0;line-height:1}.check-btn{background-color:var(--primary-color);color:#fff;border:none;padding:.75rem 1.5rem;border-radius:8px;font-size:1rem;font-weight:600;cursor:pointer;transition:background-color .2s;align-self:flex-start}.check-btn:hover:not(:disabled){background-color:var(--primary-hover)}.check-btn:disabled{background-color:#94a3b8;cursor:not-allowed}.results-section{background:var(--card-bg);padding:1.5rem;border-radius:var(--border-radius);box-shadow:var(--shadow)}.interaction-item{border-left:4px solid var(--warning);padding:1rem;margin-bottom:1rem;background:var(--bg-main, #fffbeb);border-radius:4px}.interaction-item.major{border-left-color:var(--danger);background:var(--bg-card, #fef2f2)}.interaction-item h3{margin:0 0 .5rem;font-size:1.1rem}.severity{font-size:.8rem;text-transform:uppercase;font-weight:700;display:inline-block;padding:.2rem .5rem;border-radius:4px;margin-bottom:.5rem}.severity.major{background:#fee2e2;color:var(--danger)}.severity.moderate{background:#fef3c7;color:var(--warning)}.severity.minor{background:#d1fae5;color:var(--success)}.no-interactions{color:var(--success);font-weight:600;text-align:center}